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Avance en crio-microscopía electrónica revela cómo el colesterol LDL contribuye a enfermedades cardíacas y cerebrovasculares.

New technology ‘sees’ how cholesterol causes heart attacks

31 de diciembre de 2024

El NIH de los EE.UU. utilizó la crio-microscopía electrónica para capturar imágenes detalladas del colesterol LDL, revelando cómo se acumula en las arterias y contribuye a provocar enfermedades cardíacas y accidentes cerebrovasculares. Este avance ofrece potencial para desarrollar nuevos tratamientos para la hipercolesterolemia familiar (FH por sus siglas en inglés), un trastorno genético que causa niveles elevados de LDL y ataques cardíacos tempranos. De acuerdo con el autor, el hallazgo podría conducir a medicamentos que mejoren la función del receptor de LDL, ayudando a reducir el colesterol y beneficiando a decenas de miles de personas.